Overexpression of the Oxygen Sensors PHD-1, PHD-2, PHD-3, and FIH Is Associated with Tumor Aggressiveness in Pancreatic Endocrine Tumors

Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors.

PURPOSE Tumor hypoxia is associated with poor prognosis and resistance to treatment. Our aim was to assess the expression of proteins that act as cellular oxygen sensors, directly regulating the hypoxia inducible factor (HIF) pathway, i.e., prolyl hydroxylase domain proteins (PHD)-1, PHD-2, PHD-3, and FIH in pancreatic endocrine tumors (PET). EXPERIMENTAL DESIGN Immunohistochemical expression...

What is a PhD?

This might seem like an unusual topic, as most scientists seem to know exactly what a PhD is and for what it stands. But on closer inspection, a PhD has as many meanings as there are educational systems. It is not—and has never been—a single, well-defined qualification. As research practices and funding change, the situation becomes even more confused, with consequences for the quality of both ...

Stage 2 Phd Progress Report

Open Research Problems including Integrating NLP with Database Technology Using the Database Schema to Drive the Discovery of Structure Making Use of Discovered Data and Ontologies to Support Queries Against Text Data Using Discovered Facts to Extend and Enhance Instance Data Using Discovered Structure to Extend the Database Schema and Developing a Workbench for Database Driven Structure Discovery

PhD Candidate

PhD Thesis